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レポート概要
| Mordor Intelligence社は、抗体薬物複合体（ADC）の世界市場規模が、2021年から2026年の間に年平均12.8％成長すると予測しています。本調査レポートは、世界の抗体薬物複合体（ADC）市場について調査・分析し、イントロダクション、調査手法、エグゼクティブサマリー、市場動向、製品別（アドセトリス、カドサイラ、その他）分析、用途別（血液がん、乳がん、卵巣がん、肺がん、皮膚がん）分析、技術別（クリーバブルリンカー、ノンクリーバブルリンカー）分析、標的タイプ別（CD30抗体、HER2抗体、その他）分析、地域別（北米、ヨーロッパ、アジア太平洋、中東・アフリカ、南米）分析、競争状況、市場機会/将来の見通しなどを掲載しています。 ・イントロダクション ・調査手法 ・エグゼクティブサマリー ・市場動向 ・抗体薬物複合体（ADC）の世界市場規模：製品別（アドセトリス、カドサイラ、その他） ・抗体薬物複合体（ADC）の世界市場規模：用途別（血液がん、乳がん、卵巣がん、肺がん、皮膚がん） ・抗体薬物複合体（ADC）の世界市場規模：技術別（クリーバブルリンカー、ノンクリーバブルリンカー） ・抗体薬物複合体（ADC）の世界市場規模：標的タイプ別（CD30抗体、HER2抗体、その他） ・抗体薬物複合体（ADC）の世界市場規模：地域別（北米、ヨーロッパ、アジア太平洋、中東・アフリカ、南米） ・競争状況（Seagen Inc.、ImmunoGen, Inc.、Mersana Therapeutics、Pfizer Inc.、F. Hoffmann-La Roche Ltd.、Sorrento Therapeutics, Inc.、Oxford BioTherapeutics、AbbVie Inc.、Takeda Pharmaceutical Company Ltd.、AstraZeneca、ADC Therapeutics SA、Sterling Pharma Solutions Limited、Catalent, Inc.、Antikor） ・市場機会/将来の見通し |
The antibody drug conjugates market is projected to register a CAGR of 12.8% during the forecast period.
With the COVID-19 situations pertaining across the globe, the growth of various industries registered a drop in demand, whereas several other markets remained unaffected and showed good signs of growth opportunities. COVID-19 had a different impact on different industries. The outbreak of the COVID-19 pandemic showed a strong impact on the antibody drug conjugates market because activities within hospital and healthcare services were significantly reduced due to social distancing and lockdown measures taken by governments across the globe. Moreover, the COVID-19 pandemic impacted the global economy and showed a huge impact on the operational activities of general hospitals for non-COVID-19 patients and the supply chain of ADCs across the globe. According to an article published by the American Cancer Society in 2021, there was a 52% decline in the diagnosis of breast cancer whereas, a 25% decline in the diagnosis of pancreatic cancer in March and April 2020 as compared to January and February 2020. Due to the decrease in the diagnosis of the cancer incidences, ADC market suffered a downfall.
Moreover, the major factors responsible for the growth of the antibody drug conjugates market include the growing prevalence of cancer, increasing geriatric population, and increasing Research and development activities for the development of novel therapeutics.
ADCs are the anticancer drugs which offer one of the fastest growing treatment to cancer patients, having the capacity to exploit the specificity of monoclonal antibodies towards targeted antigens for the release of potential cytotoxic drug, with an increased activity and decrease in toxicity as compared to chemotherapies. ADCs use antibodies as a vehicle to deliver highly potential cytotoxic drug molecule to the specific tumor related antigens for cancer treatment. Recent advancements in ADC technology is witnessed by the approval of 10 ADCs including Adcetris and Kadcyla specific for Cd30 and HER2 antigen sites respectively.
According to Globocan Data 2020, 50% of people having cancer are aged 65 and over and this figure is expected to double by 2040. According to the World Population Ageing article published in 2019, the share of the population aged over 65 will reach close to 16% across the globe by 2050. The World Health Organization (WHO) estimates that by 2050, 80% of older people will be living in Organisation for Economic Co-operation and Development (OECD) countries. An ageing population will have profound consequences for health systems.
Cleavable linker is one of the types of the ADC linkers which has the capacity to be cleaved by the environmental factors such as pH and redox potential and lysosomal enzymes. The different types of cleavable linkers used are pH sensitive linker (hydrazone), glutathione sensitive linker (SPDB), and protease sensitive linker (valine citrulline).
Non-cleavable linkers consist of stable bonds that resist proteolytic degradation and provide higher stability than the cleavable linkers. The system of activity of non-cleavable linkers depends on the molecularity of the ADC complex followed by breakdown of the mAb component in the lysosome, bringing about the release of a cytotoxic medication that kills tumor cells.
However, the stringent government regulations and high cost of procedures and lack of funds are expected to pull back the market growth, over the forecast period.
Key Market Trends
The Breast Cancer Segment is Expected to Account for the Largest Market Share During the Forecast Period
According to an article published in 2020 by OncLive, in 2019, approximately 15.2% of cases in the United States were found to be breast cancer incidence of all types of a new cancer diagnosis. According to Globocan Data 2020, cancer incidence is expected to increase from 19.3 million in 2020 to 30.2 million people in 2040 worldwide, whereas breast cancer incidences are expected to grow from 2.26 million people in 2020 to 3.19 million in 2040.
Initially, HER2-positive breast cancer was associated with a high rate of reoccurrence and less rate of survival. According to an article published in 2020 by Genetherapy Genetic Medicine, of all the incidences of breast cancer, HER2-positive breast cancer accounts for almost 15%. This article also says that the estimated 5-year survival rates are 83% for hormone receptor-negative, HER2-positive breast cancer, and 89% for hormone receptor-positive, HER2-positive breast cancer. With the availability of trastuzumab and other specific HER2 antigen-targeted therapies, there have been improved outcomes for this type of cancer treatment. Also, in March 2021, Pyxis Oncology and Pfizer entered into an agreement for the development and commercialization of two ADC’s candidates, PYX-201 and PYX-203for the improvement of the survival rate.
Moreover, the breast cancer segment is expected to account for the largest market share during the forecast period. ADC had shown promising results for heavily pretreated disease, CNS metastases and a targeted approach for CD30 and HER2 positive breast cancer treatment. ADCs comprise of a recombinant monoclonal antibody microscopically bound to a cytotoxic drug or payload with a manufactured linker, and they join the antibody’s high explicitness for an objective with the chemotherapy drug’s cytotoxicity. Thirteen HER2-designated ADCs tie to HER2 antigen site on the disease cell surface and are internalized by the cell, after which the cytotoxic medication segment is delivered intracellularly and applies its antitumor impact. ADCs may likewise be intended to invigorate the release of medication from the objective cell into the extracellular space, which kills encompassing and observer cells that might possibly communicate the objective antigen. The increasing research and development for the breast cancer treatment and improving the survival rate with drive the market growth for the antibody drug conjugates market.
North America is Expected to Hold a Significant Share in the Market and Expected to do Same in the Forecast Period
North America is the most COVID-influenced area across the world. Because of the flare-up of COVID-19, the market is expected to face slight difficulty in attributing to the postponement in diagnosis, drug deficiencies, and others. The Antibody Drug Conjugate Market in North America is exceptionally competitive, because of the presence of an enormous level of market players.
North America is expected to control the worldwide market rapidly because of the expanding multiplication of technologically innovative technologies in the countries of the region such as the United States, Canada, and Mexico. North America is a very developed region as far as clinical information, and the utilization of ADCs is considered and makes up the vast majority of the established market. For instance, in April 2021, Pfizer acquired Amplyx Pharmaceuticals, Inc. to develop antibody drug conjugates and several other therapies for cancer. Moreover, Asia Pacific is expected to contribute significantly to the market growth during the forecast time because of the Covid-19 flare in Wuhan Province in China and further adjoining nations.
According to the American Cancer Society, in 2020, in United States an estimated 276,480 new cases of invasive breast cancer have been diagnosed among women. Likewise, 48,530 instances of in situ breast cancer have been analyzed among ladies and the quantity of breast malignant cases is expected to grow during the forecast period. In addition, North America is found to hold a significant share of antibody drug conjugates market, and it is relied upon to show a similar pattern over the forecast time frame, without huge variances. The rising prevalence of breast cancer and the presence of better healthcare infrastructure in the region are expected to drive the overall growth of the market over the forecast period.
Competitive Landscape
The antibody-drug conjugates market is moderately competitive and consists of many players. Companies, like Seagen Inc., ImmunoGen Inc., Mersana Therapeutics, Pfizer Inc., F. Hoffmann-La Roche Ltd., Sorrento Therapeutics, AbbVie Inc. are the key players in the market. The major players are involved in strategic alliances, such as acquisitions, collaborations, and research and development activities, to secure their position in the global market.
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1 INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2 RESEARCH METHODOLOGY
3 EXECUTIVE SUMMARY
4 MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Increasing Incidence of Cancer
4.2.2 Growing Geriatic Population
4.2.3 Increasing Research and Development Activities for the Development of Novel Therapeutics
4.3 Market Restraints
4.3.1 Stringent Government Regulations
4.3.2 High Manufacturing Costs of Antibody Drug Conjugates
4.4 Porter’s Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5 MARKET SEGMENTATION
5.1 By Product Type
5.1.1 Adcetris
5.1.2 Kadcyla
5.1.3 Others
5.2 By Application
5.2.1 Blood Cancer
5.2.2 Breast Cancer
5.2.3 Ovary Cancer
5.2.4 Lung Cancer
5.2.5 Skin Cancer
5.2.6 Brain Tumor
5.2.7 Others
5.3 By Technology
5.3.1 Clevable Linker
5.3.2 Non-Cleavable Linker
5.4 By Target Type
5.4.1 CD30 Antibodies
5.4.2 HER2 Antibodies
5.4.3 Others
5.5 By End Users
5.5.1 Hospitals and Speciality Cancer centers
5.5.2 Biotechnology and Pharmaceutical Companies
5.5.3 Others
5.6 Geography
5.6.1 North America
5.6.1.1 United States
5.6.1.2 Canada
5.6.1.3 Mexico
5.6.2 Europe
5.6.2.1 Germany
5.6.2.2 United Kingdom
5.6.2.3 France
5.6.2.4 Italy
5.6.2.5 Spain
5.6.2.6 Rest of Europe
5.6.3 Asia-Pacific
5.6.3.1 China
5.6.3.2 Japan
5.6.3.3 India
5.6.3.4 Australia
5.6.3.5 South Korea
5.6.3.6 Rest of Asia-Pacific
5.6.4 Middle East and Africa
5.6.4.1 GCC
5.6.4.2 South Africa
5.6.4.3 Rest of Middle East and Africa
5.6.5 South America
5.6.5.1 Brazil
5.6.5.2 Argentina
5.6.5.3 Rest of South America
6 COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Seagen Inc.
6.1.2 ImmunoGen, Inc.
6.1.3 Mersana Therapeutics
6.1.4 Pfizer Inc.
6.1.5 F. Hoffmann-La Roche Ltd.
6.1.6 Sorrento Therapeutics, Inc.
6.1.7 Oxford BioTherapeutics
6.1.8 AbbVie Inc.
6.1.9 Takeda Pharmaceutical Company Ltd.
6.1.10 AstraZeneca
6.1.11 ADC Therapeutics SA
6.1.12 Sterling Pharma Solutions Limited
6.1.13 Catalent, Inc.
6.1.14 Antikor
7 MARKET OPPORTUNITIES AND FUTURE TRENDS